Cell culture All cell lines used are listed in Supplementary Table 1. Growth media hTert-RPE1 and MCF7 cells were cultured at 37 °C and 5% CO2 with the corresponding growth conditions: DMEM (Gibco, 11594486) supplemented with 10% fetal bovine serum (FBS; Gibco F7514) and 1% penicillin–streptomycin (Gibco 15140); KU1919 and HBLAK cells were cultured under the