hPS cell culture Derivation, maintenance and differentiation of human pluripotent stem cell lines was approved by the University of California, Berkeley Stem Cell Research Oversight Committee (protocol no. 2014-10-029). WIBR3 hES cells (National Institutes of Health (NIH) stem cell registry 0079) were initially obtained from R. Jaenisch’s laboratory62. WIBR3 hES cell lines were cultured according
Mouse models All animal experiments at the University of California Los Angeles (UCLA) were conducted in accordance with the US National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals and were approved by the Chancellor’s Animal Research Committee at UCLA. The UCLA ARC protocol numbers for the experiments were 2009-043, 2020-002, 2017-039
