Patient recruitment and sample collection Specimens were obtained from 20 patients, including histopathologically normal tissue (n = 20, flash-frozen tissue), primary tumour samples (n = 24; 16 FFPE and 8 flash-frozen tissue) and 1–7 metastases per patient (n = 80, flash-frozen tissue). Details of tissue source, location, histology, among other information, for each sample are provided in Supplementary Table 1. Autopsy
Doctors in Sri Lanka have removed a 3.1kg (6.8lb) bladder stone from a man – which they believe to be the largest of its kind on record. The procedure was carried out last week at a hospital in Trincomalee, in the east of the country. The 55-year-old patient had been admitted to hospital after suffering