A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion – Nature0

• SCIENCE, Science / Health, Science Mission Directorate, scientists, Space, Space Communications & Navigation Program, Space Launch System (SLS), Space Telescope, space-x-ipo, SpaceX
• September 11, 2026

Selection and prioritization of extracellular tumour-derived genes Candidate extracellular tumour-derived genes were identified using a stepwise filtering and prioritization strategy integrating single-cell transcriptomic analyses, protein subcellular localization annotations, functional dependency data, domain-based functional annotation and literature-based curation (Extended Data Fig. 1a). Publicly available scRNA-seq datasets from human14 and mouse15 PDAC were independently analysed. Within each