Mice All mouse handling and maintenance was performed according to the regulations of the Institutional Animal Care and Use Committee of the Albert Einstein College of Medicine (protocol 00001393). Sstflp+/+; Nos1creER+/− and Sstflp+/−;Nos1creER+/− mice were used interchangeably in this study, with no differences detected between the two groups (Nos1creER, Jax 014541; Sstflp, Jax 031629). Nos1creER+/−
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Maintenance of mouse lines All animal procedures were approved by the Austrian Federal Ministry of Women, Science and Research in accordance with the Austrian and European Union animal law (license number: BMWF-66.018/0007-II/3b/2012; BMWFW-66.018/0006-WF/V/3b/2017; GZ: 2020-0.579.989 and GZ: 2025-0.597.515). Experimental mice were bred and maintained according to regulations approved by the institutional animal care and use committee and