Cell-type-specific eQTLs underlie the genetic architecture of complex traits – Nature0

• SCIENCE, Science / Health, Science Mission Directorate, scientists, Space, Space Communications & Navigation Program, Space Launch System (SLS), Space Telescope, space-x-ipo, SpaceX
• August 27, 2026

CIGMA We developed CIGMA to unbiasedly quantify cell-type-shared and cell-type-specific eQTLs in scRNA-seq data. CIGMA avoids bias from eQTL detection power by using a linear mixed model, similar to the GREML model of complex trait heritability12. CIGMA models cell-type-specific pseudobulk data, which is computed by averaging across all cells in predefined cell types, one gene