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Planning crewed missions to the Moon and Mars involves preparing for the medical realities of long-duration space travel. Factors like cosmic radiation, microgravity, and distance from Earth create unique health considerations for astronauts. To anticipate these needs ahead of time, NASA developed the Integrated Medical Model (IMM). The IMM is a decision-support tool that uses
PPCG cohort, WGS and variant calling We used data from the PPCG consortium of primary prostate cancer samples from a total of 1,001 prostate cancer donors with 1,172 tumour samples. Informed ethical consent was obtained at clinical follow-up, and was consistent with local research ethics and International Cancer Genome Consortium (ICGC) guidelines (https://icgc.org/). Ethical approval