
Patient recruitment and sample collection Specimens were obtained from 20 patients, including histopathologically normal tissue (n = 20, flash-frozen tissue), primary tumour samples (n = 24; 16 FFPE and 8 flash-frozen tissue) and 1–7 metastases per patient (n = 80, flash-frozen tissue). Details of tissue source, location, histology, among other information, for each sample are provided in Supplementary Table 1. Autopsy
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