Screening of mouse hippocampus cells (pictured) identified an enzyme whose production rose with age. Credit: Talley Lambert/Science Photo Library An enzyme found in the brain could help to preserve cognitive resilience with advancing age, according to research in mice, humans and cells1. Researchers found that high levels of the enzyme are linked to low levels
Collection and harmonization of clinical, pathological and demographic metadata Brain tissue specimens were sourced from two brain banks: the Mount Sinai NIH Neurobiobank (MSSM) (1,042 samples) and the NIMH-IRP Human Brain Collection Core (HBCC) (300 samples). Furthermore, samples were obtained from five prospective cohort studies conducted at the Rush Alzheimer’s Disease Center (RADC) (152 samples)124,125.
Mapping microproteins in the brain might help to understand, and treat, Alzheimer’s disease.Credit: Zephyr/SPL More than 1,000 previously overlooked ‘microproteins’ have been found in samples of human brain tissue, providing researchers with the most comprehensive database yet to study these hidden molecules inside the human brain. Dozens of the tiny proteins showed altered expression in
