Collection and harmonization of clinical, pathological and demographic metadata Brain tissue specimens were sourced from two brain banks: the Mount Sinai NIH Neurobiobank (MSSM) (1,042 samples) and the NIMH-IRP Human Brain Collection Core (HBCC) (300 samples). Furthermore, samples were obtained from five prospective cohort studies conducted at the Rush Alzheimer’s Disease Center (RADC) (152 samples)124,125.
The Malva platform Malva provides a unified interface to search millions of cells by any RNA sequence. Malva integrates five modular components that operate independently but communicate through a central orchestrator (Extended Data Fig. 1b). When a user submits a query via the public RESTful API—a gene symbol, DNA sequence, or natural language request such
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