Animals SPF WT C57BL/6J (JAX, 000664) mice were obtained from The Jackson Laboratory. The following strains were also purchased from The Jackson Laboratory: Il21-VFP (B6.Cg-Il21tm1.1Hm/DcrJ, JAX, 030295)35, Il21r-knockout (B6.129-Il21rtm1Kopf/J, JAX, 019115)36, OT-II (B6.Cg-Tg(TcraTcrb)425Cbn/J, JAX, 004194)37, MD4 (C57BL/6-Tg(IghelMD4)4Ccg/J, JAX:002595)38, Jchain-creERT2 (B6(129)-Jchainem1(icre/ERT2)Deep/J, JAX, 035764)39, ROSA-DTA (B6.129P2-Gt(ROSA)26Sortm1(DTA)Lky/J, JAX, 009669)40, Ai9 (B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J, JAX, 007909)41, Thy1.1 (B6.PL-Thy1a/CyJ, JAX, 000406), AID-cre
About 5,000 homes have been evacuated and about 600 homes, businesses and other buildings have been destroyed by wildfires that remained uncontained Sunday in eastern Washington state, authorities said. The fires burned more than 8.2 square miles (about 21 square kilometers) around Spokane, the second largest city in Washington, and were among dozens across the
PUEBLO, Colorado — A wildfire burning southwest of Denver forced the evacuation of thousands of residents and destroyed more than 160 structures as of Friday as erratic winds pushed the fire across two Colorado counties. The Aspen Acres Fire is one of about 40 large uncontrolled fires burning primarily in the West, fueled by months
