Sample acquisition and preparation Samples originated from male 8-week-old Sprague Dawley rats kept in controlled conditions (12–12-h light–dark cycles, 22 °C and ad libitum access to food and water) at the University of Manchester Biomedical Sciences Facility. All tissue collection procedures were performed in accordance with the UK Animals (Scientific Procedures) Act 1986, local regulations set
VirTues architecture Multiplexed imaging data pose modality-specific challenges to the development of scalable machine learning algorithms. The images represent high-dimensional samples, characterized by a large number of measured channels and high spatial resolutions. Further, the total number as well as the combination of channels varies between datasets as studies use different marker panels. These characteristics
