Dixon, S. J. et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060–1072 (2012). Article CAS PubMed PubMed Central Google Scholar Jiang, X., Stockwell, B. R. & Conrad, M. Ferroptosis: mechanisms, biology and role in disease. Nat. Rev. Mol. Cell Biol. 22, 266–282 (2021). Article PubMed PubMed Central Google Scholar Dixon, S.
Dixon, S. J. et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060–1072 (2012).
Google Scholar
Jiang, X., Stockwell, B. R. & Conrad, M. Ferroptosis: mechanisms, biology and role in disease. Nat. Rev. Mol. Cell Biol. 22, 266–282 (2021).
Google Scholar
Dixon, S. J. & Olzmann, J. A. The cell biology of ferroptosis. Nat. Rev. Mol. Cell Biol. 25, 424–442 (2024).
Google Scholar
Fang, X., Ardehali, H., Min, J. & Wang, F. The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease. Nat. Rev. Cardiol. 20, 7–23 (2023).
Google Scholar
Neitemeier, S. et al. BID links ferroptosis to mitochondrial cell death pathways. Redox Biol. 12, 558–570 (2017).
Google Scholar
Sassano, M. L. et al. Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis. Nat. Cell Biol. 27, 642–654 (2025).
Google Scholar
Chen, X., Kang, R., Kroemer, G. & Tang, D. Organelle-specific regulation of ferroptosis. Cell Death Differ. 28, 2843–2856 (2021).
Google Scholar
Yuan, J. & Ofengeim, D. A guide to cell death pathways. Nat. Rev. Mol. Cell Biol. 25, 379–395 (2024).
Google Scholar
Moujalled, D., Strasser, A. & Liddell, J. R. Molecular mechanisms of cell death in neurological diseases. Cell Death Differ. 28, 2029–2044 (2021).
Google Scholar
Yang, W. S. et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317–331 (2014).
Google Scholar
Doll, S. et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575, 693–698 (2019).
Google Scholar
Bersuker, K. et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575, 688–692 (2019).
Google Scholar
Hou, W. et al. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy 12, 1425–1428 (2016).
Google Scholar
Yang, W. S. & Stockwell, B. R. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem. Biol. 15, 234–245 (2008).
Google Scholar
Seiler, A. et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 8, 237–248 (2008).
Google Scholar
Tobaben, S. et al. Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Differ. 18, 282–292 (2011).
Google Scholar
Gao, M. et al. Role of mitochondria in ferroptosis. Mol. Cell 73, 354–363 (2019).
Google Scholar
Fang, X. et al. Ferroptosis as a target for protection against cardiomyopathy. Proc. Natl Acad. Sci. USA 116, 2672–2680 (2019).
Google Scholar
Cui, W., Liu, D., Gu, W. & Chu, B. Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis. Cell Death Differ. 28, 2536–2551 (2021).
Google Scholar
Zou, Y. et al. Plasticity of ether lipids promotes ferroptosis susceptibility and evasion. Nature 585, 603–608 (2020).
Google Scholar
Tang, D. & Kroemer, G. Peroxisome: the new player in ferroptosis. Signal Transduct. Target. Ther. 5, 273 (2020).
Google Scholar
Gandre-Babbe, S. & Van Der Bliek, A. M. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol. Biol. Cell 19, 2402–2412 (2008).
Google Scholar
Koch, J. & Brocard, C. PEX11 proteins attract Mff and hFis1 to coordinate peroxisomal fission. J. Cell Sci. 125, 3813–3826 (2012).
Google Scholar
Itoyama, A. et al. Mff functions with Pex11pβ and DLP1 in peroxisomal fission. Biol. Open 2, 998–1006 (2013).
Google Scholar
Otera, H. et al. Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J. Cell Biol. 191, 1141–1158 (2010).
Google Scholar
Yamada, T. et al. Dual regulation of mitochondrial fusion by parkin–PINK1 and OMA1. Nature 639, 776–783 (2025).
Google Scholar
Schrepfer, E. & Scorrano, L. Mitofusins, from mitochondria to metabolism. Mol. Cell 61, 683–694 (2016).
Google Scholar
Smith, J. J. & Aitchison, J. D. Peroxisomes take shape. Nat. Rev. Mol. Cell Biol. 14, 803–817 (2013).
Google Scholar
Kim, J. et al. VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease. Science 366, 1531–1536 (2019).
Google Scholar
Cara, F. D., Savary, S., Kovacs, W. J., Kim, P. & Rachubinski, R. A. The peroxisome: an up-and-coming organelle in immunometabolism. Trends Cell Biol. 33, 70–86 (2023).
Google Scholar
Houten, S. M., Wanders, R. J. A. & Ranea-Robles, P. Metabolic interactions between peroxisomes and mitochondria with a special focus on acylcarnitine metabolism. Biochim. Biophys. Acta Mol. Basis Dis. 1866, 165720 (2020).
Google Scholar
Schoonjans, K., Staels, B. & Auwerx, J. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res. 37, 907–925 (1996).
Google Scholar
Glorieux, C., Zamocky, M., Sandoval, J. M., Verrax, J. & Calderon, P. B. Regulation of catalase expression in healthy and cancerous cells. Free Radical Biol. Med. 87, 84–97 (2015).
Google Scholar
Schrader, M. & Fahimi, H. D. Peroxisomes and oxidative stress. Biochim. Biophys. Acta Mol. Cell Res. 1763, 1755–1766 (2006).
Google Scholar
Yang, J. et al. MYC phase separation selectively modulates the transcriptome. Nat. Struct. Mol. Biol. 31, 1567–1579 (2024).
Google Scholar
Zhang, Q. et al. Visualizing dynamics of cell signaling in vivo with a phase separation-based kinase reporter. Mol. Cell 69, 334–346 (2018).
Google Scholar
Li, X., Combs, J. D., Salaita, K. & Shu, X. Polarized focal adhesion kinase activity within a focal adhesion during cell migration. Nat. Chem. Biol. 19, 1458–1468 (2023).
Google Scholar
Toyama, E. Q. et al. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science 351, 275–281 (2016).
Google Scholar
Pangou, E. et al. A PKD–MFF signaling axis couples mitochondrial fission to mitotic progression. Cell Rep. 35, 109129 (2021).
Google Scholar
Zhang, H.-L. et al. PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis. Nat. Cell Biol. 24, 88–98 (2022).
Google Scholar
Tang, S., Fuß, A., Fattahi, Z. & Culmsee, C. Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis. Cell Death Dis. 15, 626 (2024).
Google Scholar
Pedrera, L. et al. Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death Dis. 16, 40 (2025).
Google Scholar
Dolma, S., Lessnick, S. L., Hahn, W. C. & Stockwell, B. R. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3, 285–296 (2003).
Google Scholar
Larraufie, M.-H. et al. Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility. Bioorg. Med. Chem. Lett. 25, 4787–4792 (2015).
Google Scholar
Saeedi Saravi, S. S. et al. Differential endothelial signaling responses elicited by chemogenetic H2O2 synthesis. Redox Biol. 36, 101605 (2020).
Google Scholar
Sanjana, N. E., Shalem, O. & Zhang, F. Improved vectors and genome-wide libraries for CRISPR screening. Nat. Methods 11, 783–784 (2014).
Google Scholar
King, M. P. & Attardi, G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 246, 500–503 (1989).
Google Scholar
Branon, T. C. et al. Efficient proximity labeling in living cells and organisms with TurboID. Nat. Biotechnol. 36, 880–887 (2018).
Google Scholar
Victorelli, S. et al. Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature 622, 627–636 (2023).
Google Scholar
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