Maintenance of mouse lines All animal procedures were approved by the Austrian Federal Ministry of Women, Science and Research in accordance with the Austrian and European Union animal law (license number: BMWF-66.018/0007-II/3b/2012; BMWFW-66.018/0006-WF/V/3b/2017; GZ: 2020-0.579.989 and GZ: 2025-0.597.515). Experimental mice were bred and maintained according to regulations approved by the institutional animal care and use committee and