The protein catalogue gives a dynamic picture of the mitochondria, beyond what was known from humans and yeast. Credit: Dr David Furness/Keele University/SPL Scientists have mapped in unprecedented detail the proteins that make up the mitochondria in six organisms — five single-celled parasites and one plant — spanning the eukaryotic tree of life. The findings,
Some people taking the new generation of obesity drugs lose one-quarter of their body weight.Credit: Peter Dazeley/Getty Most people taking the popular GLP-1 drugs shed substantial amounts of weight — an average of one-quarter of their body weight according to one study1. So why do 10–15% of people using the drugs lose minimal weight or
Biochemist Anna Pertl typed in her question, pressed Enter and left for the night. The artificial-intelligence system that she had prompted is designed to produce innovative scientific hypotheses. But, unlike a typical chatbot, this AI tool — called Co-Scientist — doesn’t simply generate an answer in a single pass. It launches several autonomous AI systems,
Artificial-intelligence-based models of protein structure could be improved by incorporating data from pharmaceutical companies.Credit: Miyako Nakamura/Getty For drug discovery, protein-folding models such as AlphaFold have a data problem: there isn’t enough of it in public databases. Improving the performance of these artificial-intelligence-based tools will require extra data that provide examples of how proteins and drugs
Schneider, J. L., Lin, J. J. & Shaw, A. T. ALK-positive lung cancer: a moving target. Nat Cancer 4, 330–343 (2023). Article CAS PubMed PubMed Central Google Scholar Voena, C., Ambrogio, C., Iannelli, F. & Chiarle, R. ALK in cancer: from function to therapeutic targeting. Nat. Rev. Cancer 25, 359–378 (2025). Article CAS PubMed PubMed
Physicians test new narcolepsy treatments by checking whether the drugs help people to fall asleep and stay asleep throughout the night.Credit: Lucia Graphus/Alamy Earlier this month, the US Food and Drug Administration approved the first drug designed to treat the root cause of narcolepsy, a condition that affects millions of people by causing extreme sleepiness
