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Infrared absorption spectroscopy of a single polyatomic molecular ion – Nature 0
- SCIENCE, Science / Health, Science Mission Directorate, scientists, Space, Space Communications & Navigation Program, Space Launch System (SLS), Space Telescope, space-x-ipo, SpaceX
- August 28, 2026
Molecule generation Our experiment is performed on a mixed-species two-ion crystal consisting of 40Ca+ and 40CaOH+ confined in a linear Paul trap28. To form such a crystal, we first load two 40Ca+ ions and then leak in water vapour with a leak valve from a gas chamber that contains mainly water vapour with a pressure
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High-intensity sprints can trigger molecular changes in the bloodstream 0
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- August 24, 2026
We all know a sprint feels different than a longer, take-it slow kind of workout. Your heart is pounding. You gasp for air. Maybe your muscles burn. Now, new research reveals this kind of high-intensity training provokes a remarkably robust response throughout the bloodstream. The training substantially mobilizes more proteins and other molecules in the
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A biased allosteric modulator is a molecular glue for β2AR dimerization – Nature 0
- SCIENCE, Science / Health, Science Mission Directorate, scientists, Space, Space Communications & Navigation Program, Space Launch System (SLS), Space Telescope, space-x-ipo, SpaceX
- August 21, 2026
Expression and purification of β2AR in Sf9 cells The β2AR construct PN1 was expressed and purified as previously described39,42. In brief, Sf9 cells were infected with a PN1-containing baculovirus produced using the BestBac method. Cells were then collected and resuspended in chilled lysis buffer containing 10 mM HEPES, pH 7.4, 1 mM EDTA, 1 μM alprenolol and protease inhibitors
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DCAF11-dependent molecular glue degrader activated by glutathionylation – Nature 0
- SCIENCE, Science / Health, Science Mission Directorate, scientists, Space, Space Communications & Navigation Program, Space Launch System (SLS), Space Telescope, space-x-ipo, SpaceX
- August 8, 2026
Compounds dBET6 (HY-112588), dBRD9 (HY-117690), MLN7243 (HY-100487), MLN4924 (HY-70062), MG132 (HY-13259), bafilomycin A1 (HY-100558), and 5K Scaffold Library (HY-L902) were obtained from MedChemExpress. Plasmids The following plasmids were used in this study: Artichoke (Addgene #73320) and Cilantro (Addgene #74450) for flow-based reporter degradation assays, reporter CRISPR screens and co-immunoprecipitation; sgBFP (U6.sgRNA.SFFV.tBFP) for validation of DCAF11-knockout
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CRISPR gets a boost in power thanks to AI-designed ‘molecular scissors’0
- SCIENCE, Science / Health, Science Mission Directorate, scientists, Space, Space Communications & Navigation Program, Space Launch System (SLS), Space Telescope, space-x-ipo, SpaceX
- July 17, 2026
An enzyme cuts DNA (artist’s impression). Synthetic enzymes that cleave proteins were rapidly designed with the help of artificial intelligence.Credit: Artur Plawgo/Scientific Photo Library Scientists have leveraged artificial intelligence models to create synthetic CRISPR proteins that edit the genome more efficiently than their natural counterparts. These synthetic CRISPR systems could one day drive discoveries in
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