Expression and purification of SC003-mi3 VLP The mi3-VLP (also known as SC003-mi3) was derived from i3-01 (ref. 66) by introducing two mutations that remove surface-exposed cysteines to prevent aggregation and by genetically fusing a SpyCatcher domain to the N-terminus to enable plug-and-play attachment of SpyTagged proteins54. The plasmid pET28a-SpyCatcher003(SC003)-mi3 (gift from Professor Mark Howarth, Cambridge University)
Seventy years ago, the physicists Clyde Cowan and Frederick Reines took a custom-built 10-ton detector, surrounded it with thick lead walls and wet sandbags, and placed it near a powerful nuclear reactor at the Savannah River Plant in South Carolina. They called the experiment Project Poltergeist, designed as it was to catch a ghost. More
Glueballs are made of gluons, which bind quarks to form protons and neutrons.Credit: Sefa kart/Getty After almost two decades of searching, a team of physicists in China says it has observed strong evidence of a mysterious particle called a glueball that is made entirely of force-carrying particles. Researchers at the Beijing Spectrometer III (BESIII) Collaboration,
Pioneering Italian physicist Fabiola Gianotti, who led one of two experiments that led to the discovery of the Higgs boson, nicknamed the “God particle,” will be the subject of a biographical film titled “The Mystery Particle.” The high-profile biopic will be directed by Stefano Mordini (“The Invisible Witness”). Gianotti is currently the first director general
