728 x 90

GRP75-dependent SIMPA mediates inter-organellar quality control – Nature

GRP75-dependent SIMPA mediates inter-organellar quality control – Nature

Youle, R. J. & Narendra, D. P. Mechanisms of mitophagy. Nat. Rev. Mol. Cell Biol. 12, 9–14 (2011). Article  CAS  PubMed  PubMed Central  Google Scholar  Mizushima, N., Levine, B., Cuervo, A. M. & Klionsky, D. J. Autophagy fights disease through cellular self-digestion. Nature 451, 1069–1075 (2008). Article  CAS  PubMed  ADS  PubMed Central  Google Scholar  Jiao,

  • Youle, R. J. & Narendra, D. P. Mechanisms of mitophagy. Nat. Rev. Mol. Cell Biol. 12, 9–14 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mizushima, N., Levine, B., Cuervo, A. M. & Klionsky, D. J. Autophagy fights disease through cellular self-digestion. Nature 451, 1069–1075 (2008).

    Article 
    CAS 
    PubMed 
    ADS 
    PubMed Central 

    Google Scholar 

  • Jiao, H. F. et al. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Cell 184, 2896 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Quirós, P. M., Langer, T. & López-Otín, C. New roles for mitochondrial proteases in health, ageing and disease. Nat. Rev. Mol. Cell Biol. 16, 345–359 (2015).

    Article 
    PubMed 

    Google Scholar 

  • Tanaka, A. et al. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J. Cell Biol. 191, 1367–1380 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sugiura, A., McLelland, G. L., Fon, E. A. & McBride, H. M. A new pathway for mitochondrial quality control: mitochondrial-derived vesicles. EMBO J. 33, 2142–2156 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Prashar, A. et al. Lysosomes drive the piecemeal removal of mitochondrial inner membrane. Nature 632, 1110–1117 (2024).

    Article 
    CAS 
    PubMed 
    ADS 
    PubMed Central 

    Google Scholar 

  • Pickles, S., Vigié, P. & Youle, R. J. Mitophagy and quality control mechanisms in mitochondrial maintenance. Curr. Biol. 28, R170–R185 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gomez-Suaga, P. et al. The ER–mitochondria tethering complex VAPB–PTPIP51 regulates autophagy. Curr. Biol. 27, 371–385 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mishra, P. & Chan, D. C. Mitochondrial dynamics and inheritance during cell division, development and disease. Nat. Rev. Mol. Cell Biol. 15, 634–646 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bravo-Sagua, R. et al. Cell death and survival through the endoplasmic reticulum–mitochondrial axis. Curr. Mol. Med. 13, 317–329 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Harper, J. W., Ordureau, A. & Heo, J. M. Building and decoding ubiquitin chains for mitophagy. Nat. Rev. Mol. Cell Biol. 19, 93–108 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Gao, S. & Hu, J. J. Mitochondrial fusion: the machineries in and out. Trends Cell Biol. 31, 62–74 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y. & Tang, B. Z. Aggregation-induced emission: together we shine, united we soar!. Chem. Rev. 115, 11718–11940 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Shin, Y. & Brangwynne, C. P. Liquid phase condensation in cell physiology and disease. Science 357, eaaf4382 (2017).

    Article 
    PubMed 

    Google Scholar 

  • Burman, J. L. et al. Mitochondrial fission facilitates the selective mitophagy of protein aggregates. J. Cell Biol. 216, 3231–3247 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Yang, Z. T. et al. Cyclooctatetraene-conjugated cyanine mitochondrial probes minimize phototoxicity in fluorescence and nanoscopic imaging. Chem. Sci. 11, 8506–8516 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dai, Y. F. et al. Interface of biomolecular condensates modulates redox reactions. Chem. 9, 1594–1609 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen, M. C. et al. Transition-state-dependent spontaneous generation of reactive oxygen species by Aβ assemblies encodes a self-regulated positive feedback loop for aggregate formation. J. Am. Chem. Soc. 147, 8267–8279 (2025).

    Article 
    CAS 
    PubMed 
    ADS 

    Google Scholar 

  • Dai, Y. F. et al. Biomolecular condensates regulate cellular electrochemical equilibria. Cell 187, 5951–5966 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Colaiácovo, M. P. et al. Unveiling the intercompartmental signaling axis: mitochondrial to ER stress response (MERSR) and its impact on proteostasis. PLoS Genet. https://doi.org/10.1371/journal.pgen.1011700 (2025).

    Article 

    Google Scholar 

  • S pees, J. L., Olson, S. D., Whitney, M. J. & Prockop, D. J. Mitochondrial transfer between cells can rescue aerobic respiration. Proc. Natl Acad. Sci. USA 103, 1283–1288 (2006).

    Article 
    CAS 
    ADS 

    Google Scholar 

  • Friedman, J. R. et al. ER tubules mark sites of mitochondrial division. Science 334, 358–362 (2011).

    Article 
    CAS 
    PubMed 
    ADS 
    PubMed Central 

    Google Scholar 

  • Mochida, K. & Nakatogawa, H. ER-phagy: selective autophagy of the endoplasmic reticulum. EMBO Rep. 23, e55192 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hamasaki, M. et al. Autophagosomes form at ER–mitochondria contact sites. Nature 495, 389–393 (2013).

    Article 
    CAS 
    PubMed 
    ADS 

    Google Scholar 

  • Wang, Y. Metabolic regulation of misfolded protein import into mitochondria. eLife 12 RP87518 (2024).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bruderek, M. et al. IMiQ: a novel protein quality control compartment protecting mitochondrial functional integrity. Mol. Biol. Cell 29, 256–269 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wilkening, A., Rüb, C., Sylvester, M. & Voos, W. Analysis of heat-induced protein aggregation in human mitochondria. J. Biol. Chem. 293, 11537–11552 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Pfanner, N., den Brave, F. & Becker, T. Mitochondrial protein import stress. Nat. Cell Biol. 27, 188–201 (2025).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Liu, Q. et al. Nascent mitochondrial proteins initiate the localized condensation of cytosolic protein aggregates on the mitochondrial surface. Proc. Natl Acad. Sci. U.S.A. 120, e2300475120 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gorman, G. S. et al. Mitochondrial diseases. Nat. Rev. Dis. Primers 2, 16080 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Zhanghao, K. et al. Super-resolution imaging of fluorescent dipoles via polarized structured illumination microscopy. Nat. Commun. 10, 4694 (2019).

    Article 
    PubMed 
    ADS 
    PubMed Central 

    Google Scholar 

  • Li, S. G. et al. ELI trifocal microscope: a precise system to prepare target cryo-lamellae for in situ cryo-ET study. Nat. Methods 20, 276 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Li, W. X. et al. Integrated multimodality microscope for accurate and efficient target-guided cryo-lamellae preparation. Nat. Methods 20, 268 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Groeneveld, D. et al. Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice. J. Hepatol. 72, 146–155 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Zhao, L. D. et al. Tissue repair in the mouse liver following acute carbon tetrachloride depends on injury-induced Wnt/β-catenin signaling. Hepatology 69, 2623–2635 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kleiner, D. E. et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41, 1313–1321 (2005).

    Article 
    PubMed 

    Google Scholar 

  • Jiang, L. Raw data. Figshare https://doi.org/10.6084/m9.figshare.32050848.v1 (2026).

  • Jiang, L. CLEM data. Figshare https://doi.org/10.6084/m9.figshare.32050956.v1 (2026).

  • Jiang, L. Proteomics data. Figshare https://doi.org/10.6084/m9.figshare.32050986.v1 (2026).

  • For more tech updates, stay tuned to our blog.

    Posts Carousel

    Latest Posts

    Top Authors

    Most Commented

    Featured Videos