Training of snTIMs PsychAD cohort Molecular profiling efforts of the PsychAD consortium include snRNA-seq from more than 6 million nuclei from the DLPFC of 1,494 unique donors15. As described in the Capstone paper11, we utilized quadratic discriminant analysis using the 1000 Genomes Project58,59 reference to divide the full cohort into five discrete superpopulations based on
The Malva platform Malva provides a unified interface to search millions of cells by any RNA sequence. Malva integrates five modular components that operate independently but communicate through a central orchestrator (Extended Data Fig. 1b). When a user submits a query via the public RESTful API—a gene symbol, DNA sequence, or natural language request such
