Neanderthals are known to have had physiological differences from Homo sapiens, including thicker bones and defined brow ridges, as in this model.Credit: Mike Kemp/In Pictures via Getty Two genetic changes in the genomes of Neanderthals contributed to the extinct hominin’s characteristic robust physique — and the differences persist in modern humans. The variants make carriers
RESEARCH BRIEFINGS 05 August 2026 A study of more than one million people shows that rare genetic variants that disrupt the FNIP1 gene are associated with a favourable metabolic profile and a roughly 60% lower risk of cardiometabolic disease than the general population. Silencing genes in the FNIP1 pathway in mice induces fat breakdown and
The ratio of fat tissue (fat droplets in yellow; artificially coloured) to muscle mass is reduced in people with newly identified variants of a gene that affects cellular metabolism. Credit: Steve Gschmeissner/Science Photo Library A massive genomic study has linked mutations in a specific gene to an increased proportion of muscle, decreased levels of belly
Ethical approval and sample collection All necessary ethical approvals to conduct this work and to ensure that the derived organoids could be used for academic and commercial purposes were obtained from each participating clinical site for the collection of patient samples as well as for the Wellcome Sanger Institute for organoid derivation (IRAS ID:203519; REC
You have full access to this article through your institution. The Roslin Institute team was overwhelmed by media requests about Dolly.Credit: Colin McPherson/Corbis/Getty Taxidermied, encased behind plexiglass and slowly spinning on a wooden dais at the National Museum of Scotland in Edinburgh, UK, the world’s most famous sheep remains a public spectacle three decades after