Some immune cells make the long journey from the gut to membranes surrounding the brain. Credit: Steve Gschmeissner/SPL/Alamy Immune cells that fight stomach bugs can migrate from the gut to the brain, where they establish a lasting ‘memory’ of previous infection, according to a study in mice. The brain is shielded by protective membranes called
In 2004, Amy Proal got an infection that changed her life. “I was in my pre-med, last year of college, and totally tanked,” she says. “No one could tell me what it was, everybody said my blood work was fine — sent to a psychiatrist, the usual story.” She started reading papers from her sickbed
Credit: Keith Chambers/SPL Symptoms for 16 people with multiple sclerosis or other autoimmune conditions improved after receiving a treatment that produced disease-fighting immune cells inside their bodies, according to results1 from a small clinical trial. Researchers say the results are exciting but the treatment needs to be tested in more people. The latest trial, published
Skin cancer cells viewed under a microscope. Such images can reveal how the cancer spreads.Credit: NCI Center for Cancer Research/NCI/SPL The announcement on 19 August that people with melanoma who received a personalized vaccine lived longer without a cancer recurrence than those who didn’t have the vaccine is a sensation for the field. The results
Fauci, A. S. & Folkers, G. K. Pandemic preparedness and response: lessons from COVID-19. J. Infect. Dis. 228, 422–425 (2023). Article PubMed Google Scholar Rappuoli, R., Alter, G. & Pulendran, B. Transforming vaccinology. Cell 187, 5171–5194 (2024). Article CAS PubMed PubMed Central Google Scholar Pulendran, B., Li, S. & Nakaya, H. I. Systems vaccinology. Immunity
The β-galactosidase molecule can be targeted by antibodies in experiments. But some studies have erroneously used the antibody that targets the bacterial β-galactosidase instead of the mammalian version.Credit: Laguna Design/Science Photo Library More than 50 studies on cell ageing have apparently used the wrong antibody to identify a key protein in experiments, according to a
