Mice All mouse handling and maintenance was performed according to the regulations of the Institutional Animal Care and Use Committee of the Albert Einstein College of Medicine (protocol 00001393). Sstflp+/+; Nos1creER+/− and Sstflp+/−;Nos1creER+/− mice were used interchangeably in this study, with no differences detected between the two groups (Nos1creER, Jax 014541; Sstflp, Jax 031629). Nos1creER+/−
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Mice Mice were maintained on a 12 h:12 h light:dark cycle with ad libitum access to food and water, at 22 ± 2 °C and 55 ± 10% humidity. All experiments were performed in accordance with the Swiss National Institutional Guidelines on Animal Experimentation and were approved by the cantonal Veterinary Office Committees for Animal Experimentation. Male C57BL6/J mice were used for
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