Study population The genetic discovery analysis of TG:HDL ratio encompassed multiple cohorts with a cumulative sample size of 1,032,116 participants. Study participants were recruited from various population-based and hospital-based health systems across three continents (Fig. 1 and Supplementary Table 1). These cohorts included: the UK Biobank population-based study (UKB, n = 409,602)60; the Geisinger Health System MyCode
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Source and culture conditions of NextGen cancer models The source of each of the NextGen models is provided in Supplementary Table 1. In brief, breast cancer organoid models were derived by the laboratories of A.V.L., S.O. and D.L.S. Most of the NextGen CNS tumour models were derived by the laboratory of K.L.L. Colorectal and oesophagus–stomach
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Kouveliotou, C. et al. An X-ray pulsar with a superstrong magnetic field in the soft γ-ray repeater SGR1806 – 20. Nature 393, 235–237 (1998). Article ADS CAS Google Scholar Lai, D. & Ho, W. C. G. Polarized X-ray emission from magnetized neutron stars: signature of strong-field vacuum polarization. Phys. Rev. Lett. 91, 071101 (2003). Article
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Compounds dBET6 (HY-112588), dBRD9 (HY-117690), MLN7243 (HY-100487), MLN4924 (HY-70062), MG132 (HY-13259), bafilomycin A1 (HY-100558), and 5K Scaffold Library (HY-L902) were obtained from MedChemExpress. Plasmids The following plasmids were used in this study: Artichoke (Addgene #73320) and Cilantro (Addgene #74450) for flow-based reporter degradation assays, reporter CRISPR screens and co-immunoprecipitation; sgBFP (U6.sgRNA.SFFV.tBFP) for validation of DCAF11-knockout
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Conrad, M. et al. Cell death in cancer. Cell 189, 2322–2356 (2026). Article PubMed CAS Google Scholar Mao, C., Jiang, D., Koong, A. C. & Gan, B. Exploiting metabolic cell death for cancer therapy. Nat. Rev. Cancer 26, 27–45 (2026). Article PubMed CAS Google Scholar Amaria, R. N. et al. Neoadjuvant relatlimab and nivolumab in
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Bremer, G. A cytological investigation of some species and species-hybrids of the genus Saccharum. Genetica 5, 273–326 (1923). Article Google Scholar Bremer, G. Problems in breeding and cytology of sugar cane. IV. The origin of the increase of chromosome number in species hybrids of Saccharum. Euphytica 10, 325–342 (1961b). Article Google Scholar OECD/FAO. OECD-FAO Agricultural
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