Fauci, A. S. & Folkers, G. K. Pandemic preparedness and response: lessons from COVID-19. J. Infect. Dis. 228, 422–425 (2023). Article PubMed Google Scholar Rappuoli, R., Alter, G. & Pulendran, B. Transforming vaccinology. Cell 187, 5171–5194 (2024). Article CAS PubMed PubMed Central Google Scholar Pulendran, B., Li, S. & Nakaya, H. I. Systems vaccinology. Immunity
CIGMA We developed CIGMA to unbiasedly quantify cell-type-shared and cell-type-specific eQTLs in scRNA-seq data. CIGMA avoids bias from eQTL detection power by using a linear mixed model, similar to the GREML model of complex trait heritability12. CIGMA models cell-type-specific pseudobulk data, which is computed by averaging across all cells in predefined cell types, one gene
The Malva platform Malva provides a unified interface to search millions of cells by any RNA sequence. Malva integrates five modular components that operate independently but communicate through a central orchestrator (Extended Data Fig. 1b). When a user submits a query via the public RESTful API—a gene symbol, DNA sequence, or natural language request such
Crystal growth Single-crystal CrSb specimens were grown by the chemical vapour transport technique. Stoichiometric amounts of Cr (chunks, 99.995%) and Sb (Shots, 99.9999%) were used as source material. Iodine was added as a transport agent, calculated to have a pressure of 1 bar at growth conditions. The starting materials were sealed under vacuum in a quartz
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Explanation: What a sight to behold, when a night sky became filled with colors that appeared to rain over the Skógafoss waterfall in Iceland. This image was taken in a single 5 second exposure by the photographer in April 2025. Seeing an aurora is on many people’s bucket lists. But it is not easy. It requires high solar activity, dark