CIGMA We developed CIGMA to unbiasedly quantify cell-type-shared and cell-type-specific eQTLs in scRNA-seq data. CIGMA avoids bias from eQTL detection power by using a linear mixed model, similar to the GREML model of complex trait heritability12. CIGMA models cell-type-specific pseudobulk data, which is computed by averaging across all cells in predefined cell types, one gene
The Malva platform Malva provides a unified interface to search millions of cells by any RNA sequence. Malva integrates five modular components that operate independently but communicate through a central orchestrator (Extended Data Fig. 1b). When a user submits a query via the public RESTful API—a gene symbol, DNA sequence, or natural language request such
Crystal growth Single-crystal CrSb specimens were grown by the chemical vapour transport technique. Stoichiometric amounts of Cr (chunks, 99.995%) and Sb (Shots, 99.9999%) were used as source material. Iodine was added as a transport agent, calculated to have a pressure of 1 bar at growth conditions. The starting materials were sealed under vacuum in a quartz
Morris, J. L. et al. The timescale of early land plant evolution. Proc. Natl Acad. Sci. USA 115, E2274–E2283 (2018). Article CAS PubMed PubMed Central Google Scholar Lozano-Fernandez, J. et al. A molecular palaeobiological exploration of arthropod terrestrialization. Phil. Trans. R. Soc. Lond. B 371, 20150133 (2016). Article Google Scholar Lozano-Fernandez, J. et al. A
Explanation: What a sight to behold, when a night sky became filled with colors that appeared to rain over the Skógafoss waterfall in Iceland. This image was taken in a single 5 second exposure by the photographer in April 2025. Seeing an aurora is on many people’s bucket lists. But it is not easy. It requires high solar activity, dark
Almost since the first nuclear power plant started generating electricity in the 1950s, critics have pointed out the difficulty of safely disposing of highly radioactive spent fuel. In those days, radiation was among the few carcinogens that were recognized and could be measured easily. Cold-war anxieties amplified public fear of nuclear technologies and radiation. As