Epstein–Barr virus (coloured electron microscope image) is among several viruses in the body that can be reactivated by severe bouts of COVID-19.Credit: James Cavallini/Science Photo Library A severe bout of COVID-19 can wake up an army of dormant viruses hiding inside the body. That’s according to a study of more than 1,000 people hospitalized with
Lee, H. G., Lee, J. H., Flausino, L. E. & Quintana, F. J. Neuroinflammation: an astrocyte perspective. Sci. Transl. Med. 15, eadi7828 (2023). Article CAS PubMed Google Scholar Clark, I. C. et al. Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science 372, eabf1230 (2021). Article CAS PubMed PubMed Central Google Scholar
VirTues architecture Multiplexed imaging data pose modality-specific challenges to the development of scalable machine learning algorithms. The images represent high-dimensional samples, characterized by a large number of measured channels and high spatial resolutions. Further, the total number as well as the combination of channels varies between datasets as studies use different marker panels. These characteristics
Mouse models All animal experiments at the University of California Los Angeles (UCLA) were conducted in accordance with the US National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals and were approved by the Chancellor’s Animal Research Committee at UCLA. The UCLA ARC protocol numbers for the experiments were 2009-043, 2020-002, 2017-039
Plasmids and inserts Sequences and accompanying information are given in Supplementary Tables 2–4. In brief, we selected Codebook TFs (and their DBDs) from information published in a previous study1 and posted at https://humantfs.ccbr.utoronto.ca. Inserts named with a ‘-FL’ suffix correspond to the full-length ORF of a representative isoform of the protein. Those with a ‘-DBD’
Patient biospecimens and data All patient material was obtained through Memorial Sloan Kettering (MSK) Institutional Review Board protocols 06-107, 12-245, 14-244 and 22-404. No statistical method was used to predetermine sample sizes. scRNA-seq datasets from matched normal colon, primary tumour and metastasis samples were obtained from a previous study10. Patient-derived organoids from two primary tumours