Compounds dBET6 (HY-112588), dBRD9 (HY-117690), MLN7243 (HY-100487), MLN4924 (HY-70062), MG132 (HY-13259), bafilomycin A1 (HY-100558), and 5K Scaffold Library (HY-L902) were obtained from MedChemExpress. Plasmids The following plasmids were used in this study: Artichoke (Addgene #73320) and Cilantro (Addgene #74450) for flow-based reporter degradation assays, reporter CRISPR screens and co-immunoprecipitation; sgBFP (U6.sgRNA.SFFV.tBFP) for validation of DCAF11-knockout
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Public funding for science relies on a social contract: in return for support, science demonstrates its value to society. Until now, the scientific community has enjoyed a great deal of autonomy in deciding where to focus its research. But some governments are intruding on that self-regulation and narrowing how science budgets are spent — away
Epstein–Barr virus (coloured electron microscope image) is among several viruses in the body that can be reactivated by severe bouts of COVID-19.Credit: James Cavallini/Science Photo Library A severe bout of COVID-19 can wake up an army of dormant viruses hiding inside the body. That’s according to a study of more than 1,000 people hospitalized with
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