Seyfried played Holmes all the way from her time at Stanford in 2003 (where she did the titular dropping out) through to the catastrophic collapse of her company Theranos in 2015, spurred by an exposé published in The Wall Street Journal, in the 2022 Hulu limited series “The Dropout.”

Theranos purported to manufacture a device that could do a litany of blood tests from a single finger prick, but, infamously, it never actually worked. In 2022, Holmes was sentenced to 11 years in prison after being convicted of defrauding investors.

There’s speculation that Seyfried will reprise the role, in a way, as Holmes in the coming documentary “You Can See Everything,” but it’s unclear how much, if any, involvement she has in the doc.