In this study, we combine century-scale river chemistry records, reconstructed acidity and alkalinity inputs, and reactive transport simulations to evaluate whether agricultural liming in the MRB has acted as a net CO2 source or sink. We use existing long-term discharge and alkalinity flux records21 to estimate excess riverine alkalinity export relative to a pre-1935 baseline.
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Collection and harmonization of clinical, pathological and demographic metadata Brain tissue specimens were sourced from two brain banks: the Mount Sinai NIH Neurobiobank (MSSM) (1,042 samples) and the NIMH-IRP Human Brain Collection Core (HBCC) (300 samples). Furthermore, samples were obtained from five prospective cohort studies conducted at the Rush Alzheimer’s Disease Center (RADC) (152 samples)124,125.
Geim, A. K. & Grigorieva, I. V. Van der Waals heterostructures. Nature 499, 419–425 (2013). Article ADS CAS PubMed Google Scholar Liu, Y. et al. Van der Waals heterostructures and devices. Nat. Rev. Mater. 1, 16042 (2016). Article ADS CAS Google Scholar Novoselov, K. S. et al. Electric field effect in atomically thin carbon films.
MPRA design Library design To generate the catalogue of fixed human-derived substitutions we used genotyping data from 139 non-human great apes15,68,69,70,71 (10 bonobos, 59 chimpanzees, 43 gorillas and 27 orangutans), all mapped to the human reference genome GRCh37. To restrict the analysis to high-confidence genotypes, we excluded variants that did not meet any of the
